DEVELOPMENT
OF CELL CULTURE MODELS FOR TOXICOLOGICAL ASSESSMENT OF AMBIENT AIRBORNE
PARTICLES
Patrick Goegan
A thesis presented to the University
of Waterloo in
fulfilment of the thesis requirement for the degree of Master of Science
in Biology
Waterloo, Ontario, Canada, 1995
© Patrick Goegan 1995
I hereby declare that I am the sole author of this thesis.
I authorize the University of Waterloo to lend this thesis to other
institutions or individuals for the purpose of scholarly research.
I further authorize the University of Waterloo to reproduce this thesis
by photocopying or by other means, in total or in part, at the request of
other institutions or individuals for the purpose of scholarly research.
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ABSTRACT
ACKNOWLEDGEMENTS
DEDICATIONS
CHAPTER
I:
GENERAL INFORMATION
CHAPTER
II:
INITIAL ASSEMBLY OF AN ALVEOLAR CO-CULTURE MODEL
CHAPTER
III:
TOXICITY OF ATMOSPHERIC PARTICLES TOWARDS PULMONARY CELL CULTURES
CHAPTER
IV:
DEVELOPMENT OF A SEQUENTIAL CELL CULTURE MODEL FOR STUDYING THE
DYNAMICS OF PARTICLE TOXICITY
CONCLUSION
REFERENCES
APPENDIX
1
APPENDIX
2
